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Thank you so very much! Discontinue AirDuo RespiClick if such reactions occur.

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If such effects occur, AirDuo RespiClick may need to be discontinued. AirDuo RespiClick should be used with caution in patients with cardiovascular disorders, especially coronary insufficiency, cardiac arrhythmias, and hypertension. Patients with major risk factors for decreased bone mineral content, such as prolonged immobilization, family history of osteoporosis, or chronic use of drugs that can reduce bone mass e. Effect on Growth: ICS, as well as poorly controlled asthma, may cause a reduction in growth velocity, and the long-term effect on final adult height is unknown.

Patients should be maintained on the lowest dose of inhaled corticosteroid that effectively controls their asthma. Monitor growth of pediatric patients.

Regular eye exams should be considered. Coexisting Conditions: Use with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, ketoacidosis, and in patients who are unusually responsive to sympathomimetic amines. Hypokalemia and Hyperglycemia: Be alert to hypokalemia and hyperglycemia. AirDuo RespiClick is indicated for the treatment of asthma in patients aged 12 years and older.

References: 1. Advair Diskus Prescribing Information. Contraindications: AirDuo RespiClick is contraindicated in: Primary treatment of status asthmaticus or other acute episodes of asthma requiring intensive measures Patients with known severe hypersensitivity to milk proteins or any ingredients of AirDuo RespiClick Serious Asthma-Related Events—Hospitalizations, Intubations, Death: Use of LABA as monotherapy without ICS for asthma is associated with an increased risk of asthma-related death.

When LABA are used in fixed-dose combination with ICS, data from large clinical trials do not show a significant increase in the risk of serious asthma-related events hospitalizations, intubations, death compared with ICS alone Deterioration of Disease and Acute Episodes: AirDuo RespiClick should not be initiated in patients during rapidly deteriorating or potentially life-threatening episodes of asthma.

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An inhaled, short-acting beta 2 -agonist, not AirDuo RespiClick, should be used to relieve acute symptoms such as shortness of breath Excessive Use and Use with Other Long acting Beta 2 -Agonists: AirDuo RespiClick should not be used more often than recommended, at higher doses than recommended, or in conjunction with other medicines containing LABA, as an overdose may result.

Advise patients to rinse the mouth with water without swallowing following inhalation Immunosuppression: Patients who use corticosteroids are at risk for potential worsening of existing tuberculosis; fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex. Use with caution in patients with the above because of the potential for worsening of these infections Transferring Patients from Systemic Corticosteroid Therapy: Particular care is needed for patients who have been transferred from systemically active corticosteroids to ICS because deaths due to adrenal insufficiency have occurred in patients with asthma during and after transfer from systemic corticosteroids to less systemically available ICS.

Taper patients slowly from systemic corticosteroids if transferring to AirDuo RespiClick Hypercorticism and Adrenal Suppression may occur with high doses of ICS, including fluticasone propionate, or at the recommended dose in susceptible individuals.